Join us for our 11th annual Master of Translational Medicine Final Symposium! The MTM Class of 2021 has spent the past year collaborating with UCSF faculty and industry sponsors to move medical devices, novel therapies, and digital platforms closer to clinical use. This year’s symposium will feature eight student capstone teams describing their work on these exciting projects.
Zoom Webinar Join Link: https://berkeley.zoom.us/j/92647313931
Be sure to register on our Eventbrite page!
|[09:00 – 09:15am]||Opening Remarks from the MTM Faculty Director Shuvo Roy & MTM Executive Director Moose O’Donnell|
|[09:15 – 09:30am]||MTM Alumni Keynote by Megan Sullivan, Director of Product at Current Health|
|[09:30 – 09:45am]||Presentation by MelioLabs|
|[09:45 – 10:00am]||Presentation by SiMOx|
|[10:00 – 10:15am]||Presentation by Project Cool|
|[10:15 – 10:30am]||Presentation by Hydrodissection|
|[10:30 – 10:45am]||Short break, audience voting for first four presentations|
|[10:45 – 11:00am]||Presentation by Kid Cath|
|[11:00 – 11:15am]||Presentation by InCarda|
|[11:15 – 11:30am]||Presentation by Netic Health|
|[11:30 – 11:45am]||Presentation by Ear Buddy|
|[11:45 – 11:50am]||Short break, audience voting for last four presentations + panel voting|
|[11:50 – 12:00pm]||Closing Remarks|
Project Descriptions & Teams
Project Leader: Mridu Sinha (Co-Founder and CEO of MelioLabs)
Melio is committed to transforming testing for infectious disease, beginning by focusing on the neonatal sepsis market. Neonatal sepsis kills 1 million newborns annually worldwide, and affects 1-2 cases per 1,000 live births in the US alone. This fosters broad-spectrum antibiotic use, leading to poor outcomes and unnecessary costs associated with hospital stay and antibiotic overuse. Rapid diagnosis would allow for quicker, more targeted sepsis treatment for this vulnerable patient population, and this is where Melio comes in. Melio has developed a low-cost, universal platform to detect common pathogens and antibiotic resistance signatures directly from a patient sample in under 3 hours by machine learning and digital melt analysis.
This year, our MTM team has performed competitive market analysis, regulatory planning, data processing pipeline architecture design, creation of marketing materials, patent and freedom-to-operate analysis, species characterization, and reimbursement strategy.
Project Leaders: David Blauvelt, MD (Clinical Fellow, Pediatric Critical Care Medicine at UCSF)
In the United States alone, ~25,000 newborns are born extremely premature (EPT) with high mortality due to their severely undeveloped lungs. Although current NICU technology enables survival, there is a definitive need for life support that mitigates resulting severe chronic complications associated with this vulnerable population. SiMOx-AP is a novel artificial placenta oxygenator that provides respiratory support that mimics placental gas exchange to overcome key clinical obstacles in EPT care. In collaboration with UCSF’s Roy Lab, our team has significantly contributed to engineering a second-generation device and performing analyses on business strategy, regulatory approach, and intellectual property review to ultimately help change the paradigm of neonatal care and improve EPT patient outcomes.
Project Leader: Sanjay Dhall, MD (Director of Spinal Neurotrauma at UCSF)
Great Circle Technologies, Inc (GCT) has developed a novel, minimally invasive and simple technology for local cooling of the spinal cord. This procedure could be widely used in emergency situations to “buy time” prior to surgery for spinal cord injury (SCI) patients, help the patient to achieve better recovery after the SCI, and has a potential role in military battlefield SCI treatment in combat support hospitals. The device consists of a thermally conductive catheter, a cooling system and an interface that combines the two. This device can be utilized by physicians in a standard bedside procedure.
Project Leaders: Miles Conrad, MD (Clinical Professor of Radiology at UCSF) & Philip Messersmith, PhD (Professor of Materials Science and Engineering at UC Berkeley)
We are presenting a novel injectable hydrogel material to be utilized for separating tissues during percutaneous thermal ablation procedures. Thermal ablation is a procedure commonly used to heat or cool kidney and liver tumors to cytotoxic temperatures. However, there remains a significant unmet need in clinical strategies for mitigating damage to adjacent tissues and organs. This year our team interviewed stakeholders including UCSF proceduralists in various departments, helped secure additional UCSF Catalyst funding, and designed a regulatory/reimbursement strategy surrounding bringing our gel to market. Our hydrogel will improve user experience and save time compared to the current standard of care (hydrodissection) while reducing both complications and costs associated with thermal ablation.
Project Leaders: Grant Wells (Director of Innovation & Development at Stanford) & Avnesh Thakor (Inventional Radiologist and Assistant Professor at Stanford)
Current pediatric hemodialysis catheters come with an array of complications that subject children to unnecessary discomfort, increased risk of arrhythmia, poor dialysis, and thrombosis. In collaboration with Stanford’s Maternal and Child Health Research Institute and Thakor Lab, Kid Cath aims to create a market analysis, regulatory strategy and expand clinical indications for a modular hemodialysis catheter, designed to meet the needs of hemodialysis pediatric patients.
Project Leaders: Carlos Schuler, PhD (Chief Operating & Technology Officer & Co-Founder of InCarda), Luiz Belardinelli, MD, (CMO and Co-Founder of InCarda), Jeff Ho (Vice President of Commercial Strategy at InCarda), and Debra S. Echt, MD (SVP of Medical Affairs)
Atrial Fibrillation (AF) is the most common cardiac arrhythmia affecting over 6 million people with an annual cost of $10.1B in the US alone, and approximately 30-40% of this population have Paroxysmal Atrial Fibrillation (PAF). InCarda therapeutics is developing a novel medication called InRhythm that is a nebulized formulation of an antiarrhythmic medication called flecainide acetate. This novel medication provides the symptomatic PAF patient the treatment option of self-administering the orally inhaled flecainide, and provides acute cardioversion to sinus rhythm via the lung delivery route. InRhythm can be self-administered by patients on an outpatient basis as needed compared to the costly current standard of care that involves emergency services, and a likely hospital admission. The MTM team is developing the infrastructure for InCarda’s treatment paradigm that includes a stakeholder analysis of the combination of wearable devices, telehealth platforms, reimbursement strategy, and a market analysis. The MTM team’s efforts will potentially improve InRhythm’s market entry and user adoption that includes increased prescriptions to patients, and revenues. Patients will be empowered to self-treat their PAF at home, with an optional form of clinical support via telemedicine that includes remote monitoring and wearable devices.
Project Leader: Mathias Vissers, MD, MTM (Co-Founder of Netic Health)
The current system of physical therapy is fragmented, and prevalent chronic injuries frequently derail the careers of athletes. Netic Health aims to solve this problem through a digital care platform for physical health and physical therapy. We connect patients with personalized, athletic-focused physical therapists and treat them using telehealth, chat-based care and artificial intelligence in order to make the care 10x more affordable and 10x more accessible. After conducting interviews to understand the tight-knit running community, the MTM team has analyzed clinical indications to refine the business model, performed a market analysis, helped implement an advertising campaign, and helped manage two pilot studies with paying customers.
Project Leaders: Matthew Oldakowski, PhD (Director at Perth Biodesign), Peter Santa Maria, MD, PhD (Surgeon and Assistant Professor of Otolaryngology at Stanford) & Paul Yock, MD (Director, Stanford Byers Center for Biodesign)
Otitis Media with Effusion (OME) or ‘glue-ear’ is an extremely common disease in children, causing discomfort, hearing difficulties, and developmental delays. Currently, the American medical system spends $1.9B on OME management per year. EarBuddy is an affordable, novel, non-invasive device that can be used to deliver a positive pressure therapy to the middle ear to drain the effusion and resolve OME. This year, our team has completed stakeholder interviews with pediatricians and ENT specialists, identified our total addressable market size, developed a reimbursement strategy based on our health economics analysis, and designed clinical trials. We are also in the process of finalizing our 510(k) technical dossier for submission and setting up our quality management system and manufacturing.
Shuvo Roy, PhD
Faculty Director of the MTM Program
Dr. Shuvo Roy is the Faculty Director of the MTM Program, a professor in the UCSF Department of Bioengineering and Therapeutic Sciences (BTS), and director of the Biodesign Laboratory at the Mission Bay Campus. He is the Technical Director of The Kidney Project, a national research project with a goal to create a small, surgically implanted, and free-standing bioartificial kidney to treat end-stage renal disease.
Michael “Moose” O’Donnell, PhD
Executive Director of the MTM Program
Moose O’Donnell is the Executive Director of the MTM Program working across both campuses to create the joint University experience for the students. He also oversees recruitment of new projects for MTM teams; to discuss sponsoring a project, please contact him at email@example.com.
Dan Burnett, MD, MBA
Industry Director of the MTM Capstone Course
Dr. Burnett, a CEO of TheraNova, received his M.D. from Duke University and concurrently obtained an M.B.A. from Duke’s Fuqua School of Business. Since 2006 Dr. Burnett has raised over $100MM for the seven TheraNova spinouts. He is an inventor on 15 issued patents and over 200 patents pending worldwide. He recently joined University of California San Francisco as an entrepreneur in residence with QB3 and as adjunct faculty in the Bioengineering Department.
|Dorian Liepmann, PhD
Faculty Director, Vice Chair of the Master’s Programs at UC Berkeley
Dorian Liepmann is a professor in the Departments of Bioengineering and Mechanical
MTM Student Bios
Before joining the MTM program, Sydney Adams graduated with a B.S. in Biochemistry from Loyola Marymount University. She has gained experience in the pharmaceutical industry through her roles as a summer fellow at the USC School of Pharmacy and intern at Gilead Sciences in Medicinal Chemistry. Sydney’s diverse experience in pharma has allowed her to gain a thorough understanding of the academic and professional concepts required to bring therapeutics to market. Through the MTM, she has leveraged market research and data analysis to bring a real-world medical device to commercialization.
Plans after graduation: Sydney will be joining Gilead Sciences as a Sr. Research Associate in Analytical Operations! In this role, Sydney will be completing four, six-month rotations within the pharmaceutical development manufacturing group. Connect with Sydney on LinkedIn.
|Cindy Arregoitia Sarabia
Cindy Arregoitia is motivated by impact. She has always known she wanted to help and contribute people. As a clinician, she found she can impact many lives by facilitating innovation in the healthcare industry to better overall healthcare services. Her background includes a medical degree from National Polythecnic Institute in Mexico with 2 years of medical practice experience in primary care and 3 years of research experience in the field of cardiovascular, metabolic, infectious disease and neuroscience. During her Master’s program, she focused in understanding clinical research, statistical data and methodology for industry and academic trials.
Plans after graduation: For the future she plans to transition into liaison between clinical science and medical affairs to be the link between clinical research and commercialization in order to help deliver technologies to the ones who need it the most and fulfill clinical unmet needs. Connect with Cindy on LinkedIn.
Hang is a recent graduate from UC San Diego with majors in biology and clinical psychology. She is passionate about making an impact in healthcare and bridging gaps in medicine translation. Her past experience includes basic biology research, clinical research, and business strategies in healthcare industry. With her graduation from UC Berkeley, she is inspired to explore her potentials in the biotechnology field, participate in clinical research processes and discover better treatments to deliver to patients.
Plans after graduation: Upon graduation, Hang is planning to participate in clinical research as Clinical Research Coordinator or Clinical data manager, to learn more about clinical research, medicine translational process and U.S. healthcare structure in general. Connect with Hang on LinkedIn.
Yu-Jing received his Bachelor’s degree in Business Administration and a minor degree in Biochemical Science and Technology at National Taiwan University. He also had worked for biotech and medical device startups doing business development. He aims to contribute his knowledge and skills in business and life science to bring innovative solutions to solve clinical unmet needs.
Plans after graduation: Yu-Jing is looking for opportunities in the biotech industry where he can apply his skills in business and life science to support the process of bringing healthcare innovation to market. Connect with Yu-Jing on LinkedIn.
Mason is a product manager and biomedical engineer looking to leverage his experience in the digital health and medical device fields to build products that will help patients receive better care.
Plans after graduation: Mason is seeking a product management role at a digital health or medical device company after graduation. Connect with Mason on LinkedIn.
Keerthana joined the MTM program after completing her B.S. in Bioengineering and Computer Science minor at UC Berkeley. She has 2 years of research experience in biomaterials and has taught undergrads within the bioengineering department for 3 years. Her experiences with Melio as an MTM intern, UCSF Innovation ventures as a Catalyst intern, and Illumina as a lifecycle management intern developed her interest in systems-level product development. In future roles, she hopes to support end-to-end medical device development and plans to build a career in medical device technical product management.
Plans after graduation: After graduating, Keerthana will be joining the Systems Integration team at Element Biosciences in San Diego. Connect with Keerthana on LinkedIn.
Anjali has a B.S. in Biomedical Engineering from the University of Southern California and over 2 years of academic research experience. Through the MTM program, she has been working with SiMOx to help engineer a second-generation prototype and develop the clinical, market, and regulatory strategies for an artificial placenta oxygenator device for extremely preterm infants. Anjali is passionate about using her bioengineering and MTM background to contribute to addressing the current gaps in healthcare for vulnerable populations.
Plans after graduation: Anjali is seeking clinical development or field clinical engineering roles at the intersection of R&D and clinical needs-finding. Connect with Anjali on LinkedIn.
Prior to MTM, Raman graduated from UW Madison with a B.S. in Material Science & Engineering, Biochemistry, and Biology. She is passionate about harnessing the potential of stem cells for use in the next generation of off-the-shelf therapeutics. Raman has over three years of research experience in cardiovascular regenerative medicine, and hopes to use the knowledge gained during MTM to develop translatable cellular therapies for patients.
Plans after graduation: After graduating, Raman will be working at Caribou Biosciences in Berkeley researching and developing stem cell derived immune therapies to treat cancer. Connect with Raman on LinkedIn.
Previously, Varun graduated from UC San Diego with a BS in Bioengineering and Biotechnology. His background includes 3 years of developing novel clinical and medtech technologies, including a patent for an early cancer diagnostic. Through the MTM program and his work with the EarBuddy capstone team, he has gained a deeper understanding of regulatory pathways, go-to-market strategies, and financing approaches for early-stage medtech. Varun is also an avid supporter of STEM education for underrepresented minorities, and has worked on several programs focused on scientific empowerment.
Plans after graduation: Varun is focused on building and commercializing novel technologies that can improve the cancer care journey. After the MTM, he will go full-time on his startup, Epinoma, which is focused on building a novel monitoring test for colon cancer patients. Connect with Varun on LinkedIn.
Dr. Wendy Gulden is a 20 year experienced endodontist interested in the intersection of medicine, business and social impact. Wendy’s capacity to drive organizational production and performance has proven instrumental in achieving stated goals and objectives. Her drive and cross-functional collaborative strategies have given her success in professional disciplines in management, lean transfer marketing and market research. Wendy embraces her capacity to drive customer excellence as her top priority.
Plans after graduation: After graduation, Wendy is looking forward to taking on a position where she can apply her skills in healthcare innovation and clinical applications. Connect with Wendy on LinkedIn.
|Amber Hafterson, BSN, RN
Amber found her passion for helping others while serving active duty in the US Army as a Combat Medic. She continued her service after retiring from the military by working as an RN in the emergency room for several years. This year she worked with InCarda Therapeutics who is developing a novel medication for patients affected by paroxysmal atrial fibrillation. She recently launched a life science startup to help diabetic patients live safer lives, and is looking forward to helping patients have improved clinical outcomes across all spectrums of healthcare.
Plans after graduation: Amber is excited to combine her extensive clinical skills with the knowledge acquired through the MTM program to continue to her passion for helping others on a broader scale. After an adventurous sabbatical, Amber will consider roles that provides an opportunity to make a positive impact for the health and welfare of our society. Connect with Amber on LinkedIn.
Tong is a technical product manager combining her technical background in software engineering, machine learning, web development, and data analysis with her love for communication and designing creative digital solutions to solve problems to positively impact lives.
Plans after graduation: Tong will be joining Medable Inc. to help get effective therapies to patients faster as a Product Manager. Connect with Tong on LinkedIn.
|Timothy Alton King, Jr.
Timothy has a B.S. in Biological Engineering with a Business Administration minor from Louisiana State University (’20). There, Timothy gained two years of breast cancer research experience, along with the development of a proximity detection sensor system for visually impaired equestrians. Through the MTM, he has leveraged his background to further prototype development of a localized cooling catheter to treat acute spinal cord injury. He is passionate about bridging the gap in novel medical device development for a greater impact on public health.
Plans after graduation: Timothy’s next aims are to remain within MedTech in a Product Development/Management role to blend his unique background, leadership attributes, and wholistic perspective of healthcare innovation. In this way, he will bridge the gap between clinical research and product commercialization to enhance the public’s access to impactful medical devices and decrease the healthcare inequity gap. Connect with Timothy on LinkedIn.
Before the MTM, Artiom completed an M.S. in engineering in France. He then worked for one year as a Consultant in Regulatory Affairs. There, he helped clients all around Europe to tackle regulatory tasks, such as risk analyses for medical devices, but also qualification and validation requirements. During his year at the MTM, Artiom worked as part of the Earbuddy team, building the go-to-market strategy.
Plans after graduation: Artiom is seeking opportunities to help developing healthcare businesses. Connect with Artiom on LinkedIn.
Daniel is technically trained as a bioengineer from University of the Pacific. Prior to the MTM program, Daniel worked in quality engineering for an IVD startup and consulted at a tissue engineering incubator company. During the MTM, he worked on a pediatric device aiming to treat glue-ear to develop their 510(k) technical dossier. He hopes to continue assisting medical devices through addressing their quality and regulatory strategies after graduation.
Plans after graduation: After graduation, Daniel is seeking positions where he work in quality and regulatory to support business processes and healthcare innovations. Connect with Daniel on LinkedIn.
Monica has a bachelor’s degree in bioengineering. She has prior experience working in clinical, biomaterial and bioprinting research laboratories both in academic and government lab settings. Her capstone involves an artificial placenta oxygenator device where she and her team have developed the business strategy, market, clinical trials, and stakeholder interviews. Monica has led the team in developing the optimal regulatory strategy.
Plans after graduation: She is eager to pursue a position in medical device industry where she will be able to create and bring novel medical innovation from labs to patients in need. Connect with Monica on LinkedIn.
Through her undergraduate degree in Public Health at UC Berkeley, Jess learned how patients can be neglected by our healthcare system. Exploring medical device research and bioengineering courses showed her how medical innovation ideas could be neglected as well. Jess joined the MTM to learn how to transform cutting-edge bench research into real world clinic solutions for her future patients. This year, she focused on engaging stakeholders, pursuing FDA approval, and designing a safety and efficacy clinical study to promote adoption of the adjustable pediatric hemodialysis catheter.
Plans after graduation: After graduation, Jess is looking for a Bay Area position in clinical research to help translate medical innovation to clinical application. In the future, she hopes to use the skills she learns to increase healthcare quality and equity for her future patients. Connect with Jessica on LinkedIn.
Reuben feels incredibly privileged to be living in this amazing time of a biomedical research and data science explosion, where translating fundamental discoveries into new diagnostic and therapeutic approaches for human illnesses is now a reality.
As he continues to learn and gain more experience, he hopes he can use the tools and skills he has acquired to better elucidate the biological and sociological factors that contribute to neurological disorders in order to develop novel treatments and therapeutics.
Plans after graduation: After graduation, Reuben hopes to gain more experience working with diagnostic/therapeutic startups, and building his application for medical school. Connect with Reuben on LinkedIn.
Zach is a research scientist who is passionate about developing low-cost, accessible medical technologies. After earning a B.S. in Biology from San Diego State University, where he gained research experience in organic chemistry and marine ecology, Zach joined Google [X]’s life sciences start-up (now Verily) in 2013. He spent six years at Verily as an associate scientist working on precision nanomedicine. Zach joined the MTM program to develop business and regulatory expertise to bolster his research experience and gain the tools necessary to start a company in the future.
Plans after graduation: After graduation, Zach plans to continue working as an independent consultant while vetting business ideas to form his own company. Connect with Zach on LinkedIn.
Aarushi is a dedicated, detail-oriented bioengineer from UC Berkeley with a passion for translating novel medical technology into clinical application. She has developed device design skills working for ophthalmology bioengineering labs and predictive health companies in the Bay Area in the last 4 years. Currently, as technical design lead for SiMOx-AP, she is managing R&D, regulatory, and business strategies to help engineer a second-generation microfluidic oxygenator and assess its complete product development pathway to commercialization. Her ultimate career goal is to generate a positive impact on patient lives.
Plans after graduation: After graduation, Aarushi intends to leverage her bioengineering, regulatory, and entrepreneurial skill sets to focus on a biotech career in product management. Connect with Aarushi on LinkedIn.
Neeki joined the MTM program with a B.S. in Neurobiology, Physiology, and Behavior from UC Davis with experience in clinical research with UC Davis Health Obstetrics and Gynecology and Emergency Medicine. Additionally, she researched and published two papers on ovarian cancer and genetic mutations through the UC Davis Department of Biochemistry and Molecular Medicine. She has experience in health ventures as well through working with Plug and Play Health. This year, Neeki worked on the Pediatric Modular Catheter with the KidCath team to develop a more efficient hemodialysis catheter.
Plans after graduation: Neeki aims to continue to translate medical technology into clinical applications. She currently open to and seeking different career opportunities, and is particularly interested in Regulatory Affairs, Clinical Development, and Product Management. Connect with Neeki on LinkedIn.
Divek graduated from UCSD with a degree in bioengineering. Prior to joining the MTM, Divek worked as a medical scribe. He is passionate about using his engineering background to improve patient lives. As part of the Netic Health MTM capstone team, he had the opportunity to explore his passion by helping to develop a digital health solution for physical therapy.
Plans after graduation: Divek will be attending medical school beginning next year and looks forward to continuing to develop his skills in innovation, entrepreneurship, and research. Connect with Divek on LinkedIn.
Neel graduated from Emory University with a B.A. in History and Political Science. He is currently a medical student pursuing an M.D. at New York Medical College. During medical school he worked at the University of Colorado Health system as a Health Innovation Fellow where he used HCD to improve patient flow to inpatient teams and improve communication and collaboration between the emergency department and department of hospital medicine. Before medical school he served as a U.S Army officer leading teams of up to 40 people.
Plans after graduation: Neel plans to pursue a residency in internal medicine and a fellowship in critical care medicine. Connect with Neel on LinkedIn.
|Mia von Knorring
Mia is driven to create innovations in the cardiovascular and structural heart medical device world. She received a B.S. in Biomedical Engineering from Cal Poly, SLO then continued to the MTM program to expand her career possibilities. She has had many R&D engineering roles around the Bay Area, working in structural heart, stroke and vascular disease spaces. She worked designing prototypes, creating design validation test methods and conducting PMA submission testing. Her work at 3 startups inspired her to want to start her own company after working for a larger company for a few years to learn a different side of the industry.
Plans after graduation: Through the MTM, Mia found a passion for the marketing side of the industry and recently accepted a job as a Product Manager in Upstream Marketing for Abbott in their High Voltage Therapies division in LA. Connect with Mia on LinkedIn.
|Tongyu (Jessica) Zhang
Tongyu (Jessica) Zhang is passionate about delivering innovative technologies into real life to help people gain better access to healthcare technology and quality of care. Her background includes a bachelor degree in Biology at UCLA with 3 years research experience in the field of Genomic, neuroscience, and bioengineering and also working in a Genomic company doing international business development. During her Master’s program, she joined a variety of different start-ups as product manager/business strategy consultant. At the same time, while taking many MBA classes from Haas School of Business, her MTM capstone project is working on combining drugs, wearable devices and telehealth. After graduation, she will work at the intersection of research, clinical needs, and commercialization.
Plans after graduation: She is seeking life science consultant and product manager roles to improve clinical access and health outcomes. Connect with Tongyu on LinkedIn.
Prior in pursuing the MTM program, Maggie graduated from University of Wisconsin-Madison with a degree in biomedical engineering that focuses on biomechanics track. She participated in several undergraduate design projects that began from the client’s design inquiries to the devices’ R&D. The process prepared her well of launching a medical device from the early stage. She had an internship at Pfizer R&D Center in Shanghai during 2019 summer. Her professional interests are focusing on overviewing the whole product development process, including the R&D stages and the later marketing stages.
Plans after graduation: After graduation, Maggie is looking for a position that could combine her biomedical engineering and translational medicine background in the product management career pathway. Connect with Maggie on LinkedIn.